Selenium and vitamin E deficiency impair transferrin receptor internalization but not IL-2, IL-2 receptor, or transferrin receptor expression
| Autor: | C. Channa Reddy, Mary Lou Eskew, Lorraine M. Sordillo, Gina M. Pighetti |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Vitamin medicine.medical_specialty medicine.medical_treatment Immunology Down-Regulation Transferrin receptor Lymphocyte proliferation Biology Lymphocyte Activation Calcitriol receptor Selenium chemistry.chemical_compound Internal medicine Receptors Transferrin medicine Animals Immunology and Allergy Vitamin E Deficiency Lymphocytes Receptor chemistry.chemical_classification Vitamin E Receptors Interleukin-2 Cell Biology Endocytosis Rats Endocrinology chemistry Transferrin Interleukin-2 Vitamin E deficiency |
| Zdroj: | Journal of Leukocyte Biology. 63:131-137 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1002/jlb.63.1.131 |
| Popis: | Vitamin E and Se deficiency increase the risk of disease by impairing the immune response. To aid in the understanding of how vitamin E and Se deficiency reduce immune competence, this study examined several mechanisms necessary for lymphocyte proliferation. Weanling rats were fed a vitamin E-deficient, selenium-deficient, or control diet for 8 weeks. At this time splenic mononuclear cells were isolated and stimulated with concanavalin A for 48 h. Although the percentage of lymphocytes and monocytes capable of proliferating were consistent among the dietary groups, lymphocyte proliferation was decreased significantly in vitamin E- and selenium-deficient rats. This decrease in proliferation was not associated with alterations in interleukin-2, interleukin-2 receptor, or transferrin receptor expression. However, stimulated cells from vitamin E- and Sedeficient rats internalized few if any transferrin receptors. Reduced transferrin receptor internalization may limit lymphocyte expansion by depleting the intracellular iron stores needed for cellular function and proliferation. |
| Databáze: | OpenAIRE |
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