Raised plasminogen activator inhibitor-1 (PAI-1) is not an independent risk factor in the polycystic ovary syndrome (PCOS)
| Autor: | Steve Shaw, Terence J. Wilkin, Robert Fox, J. E. Condon, J Friend, Archibald G. Prentice, William Atiomo |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Body Mass Index Anovulation chemistry.chemical_compound Endocrinology Insulin resistance Risk Factors Internal medicine Plasminogen Activator Inhibitor 1 medicine Humans Insulin Triglycerides Free androgen index Polycystic ovary syndrome (PCOS) Cholesterol HDL Luteinizing Hormone medicine.disease Polycystic ovary Cholesterol Cross-Sectional Studies chemistry Case-Control Studies Plasminogen activator inhibitor-1 Androgens Regression Analysis Female Follicle Stimulating Hormone Insulin Resistance Plasminogen activator Polycystic Ovary Syndrome |
| Zdroj: | Clinical Endocrinology. 52:487-492 |
| ISSN: | 0300-0664 |
| DOI: | 10.1046/j.1365-2265.2000.00946.x |
| Popis: | Summary BACKGROUND It has been postulated that an insulln-driven increase in plasminogen activator inhibitor-1 (PAI-1) levels may link insulin resistance to anovulatory infertility in women with PCOS and that It may place them at increased risk of thromboembolic disease. However, previous studies have been conflicting because many have failed to control for body mass index (BMI) which may affect PAI-1. The aim of this study was to investigate PAI-1 activity in women with PCOS and to compare it with unaffected controls of a similar BMI. DESIGN AND PATIENTS 41 Women with Pcos and 25 weight-matched controls participated in this cross-sectional study. Patients were evaluated clinically and by pelvic ultrasound and fasting blood samples were taken for haematological and biochemical tests. MEASUREMENTS PAI-1 activity, insulin, glucose, trlglycerides, total cholesterol, LDL cholesterol, HDL cholesterol, FSH, LH, PRL, testosterone, SHBG, 17–hydroxyprogesterone, plasminogen, fibrinogen (α2 antiplasmin, blood pressure and insulin sensitivity with a homeostasis model assessment (HOMA) computer programme. RESULTS There was no significant difference in BMI or in (log) PAI-1 activity in women with PCOS compared with controls (BMI 29.5 ± 5.6 vs. 28.4 ± 6.3 kg/m2, P=0.25 and PAI-12.56 (SD 0.85) vs. 2.14 (SD 0.98) au/ml, P=0.07). The median fasting insulin level was significantly higher (17 (4.6–134.5) vs. 9.6 (3.7–41.5) mU/l, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text