Orexin-A immunoreactive neurons in the rat hypothalamus do not contain neuronal nitric oxide synthase (nNOS)
| Autor: | Jonathan R.S. Arch, Richard Morris, Ron A. Leslie, Martyn L. Evans, Gareth Williams, David J. Cutler |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Physiology Cell Hypothalamus Neuropeptide Nitric Oxide Synthase Type I Biochemistry Energy homeostasis Nitric oxide Cellular and Molecular Neuroscience chemistry.chemical_compound Orexin-A Endocrinology Internal medicine mental disorders medicine Animals Rats Wistar Neurons Orexins biology Neuropeptides digestive oral and skin physiology Intracellular Signaling Peptides and Proteins Immunohistochemistry Rats Orexin Nitric oxide synthase medicine.anatomical_structure nervous system chemistry biology.protein Nitric Oxide Synthase Carrier Proteins |
| Zdroj: | Peptides. 22:123-128 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(00)00364-8 |
| Popis: | The lateral hypothalamic area (LHA), a key site involved in the central control of feeding and energy homeostasis, contains populations of neurons that produce the orexin peptides or nitric oxide, two chemical factors that increase food intake. In this study, we used immunohistochemistry to investigate the possibility that rat LHA neurons co-express orexin-A and neuronal nitric oxide synthase (nNOS). The orexin-A and nNOS cell populations in the LHA showed extensive overlap without co-localization, and no evidence of direct anatomic contact was found. The finding that LHA neurons do not co-localize orexin-A and nNOS may suggest that the actions of the orexins and nitric oxide on food intake are mediated via independent mechanisms, however, nitric oxide is a diffusible molecule and could potentially affect the activity of orexin neurons via a non-synaptic mechanism. |
| Databáze: | OpenAIRE |
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