EXAMINATION OF THE LIPID PROFILE IN PREGNANT OBESE WOMEN, CONSIDERING THE ALLELE STATUS OF THE GENES OF ANGIOTENSIN-CONVERTING ENZYME (ACE I / D) AND PLASMINOGEN-1 (PA-1 4G / 5G) ACTIVATOR-INHIBITOR
| Autor: | Marina Dmitrуina Gresko, Vasyl Yefremovych Rynzhuk, Kateryna V. Vlasova, Vitaliy V. Maksimyuk, Tetiana A. Glushchenko, Yuriy O. Malyshevskyi, Violeta G. Khomenko, Mariana I. Kryvchanska, Larisa P. Sydorchuk, Larisa Vasylivna Rynzhuk, Victor M. Batig, Tetiana S. Bulyk |
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| Rok vydání: | 2018 |
| Předmět: |
obesity
lcsh:R5-920 medicine.medical_specialty medicine.diagnostic_test biology business.industry Activator (genetics) lcsh:R PAI-1gene polymorphism lcsh:Medicine Angiotensin-converting enzyme General Medicine lipids Endocrinology Internal medicine ACE gene polymorphism medicine biology.protein pregnancy Allele lcsh:Medicine (General) Lipid profile business Gene |
| Zdroj: | Archives of the Balkan Medical Union, Vol 53, Iss 2, Pp 205-209 (2018) |
| ISSN: | 2558-815X 1584-9244 |
| DOI: | 10.31688/abmu.2018.53.2.05 |
| Popis: | Changes in the lipid profile in pregnant women, with and without obesity, have been studied depending on the angiotensin-converting enzyme (ACE) gene I/ D polymorphism and the 4G5G polymorphism of the plasminogen activator inhibitor type I (PAI-1). The combination of the D-allele of the ACE gene and the 5G allele of the PAI-1 gene is a risk factor of increasing total cholesterol in pregnant women, regardless of the obesity class, and of increasing triglycerides in pregnant women without obesity. The presence of the D-allele of the ACE gene in the haplotype, regardless of the combinations of the genotypes of the PAI-1 gene, is a risk factor of increasing triglycerides in pregnant women with obesity. |
| Databáze: | OpenAIRE |
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