General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity
| Autor: | H. Scott Swartzwelder, Jenna M. Carter, Jessica L. Santerre-Anderson, Magdalena Palac, Scott D. Moore, Lisa M. Savage, David F. Werner, Linda P. Spear, Yvette Dzumaga, Justine D. Landin, Gina M. Fernandez, Rebekah L. Fleming, Elena I. Varlinskaya |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Anesthetics General Dendritic Spines Prefrontal Cortex Hippocampus Impulsivity Adolescent age Article Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience Cognition 0302 clinical medicine Neuroplasticity Animals Medicine Prefrontal cortex Pharmacology Neuronal Plasticity Behavior Animal Isoflurane business.industry Pyramidal Cells Rats Affect 030104 developmental biology Impulsive Behavior Anesthetic Synaptic plasticity Exploratory Behavior medicine.symptom business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuropharmacology |
| ISSN: | 0028-3908 |
| Popis: | Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general anesthetics are not well understood. Adolescence is a critical developmental period wherein multiple late developing brain regions may also be vulnerable to enduring general anesthetic effects. Given the breadth of the adolescent age span, this group potentially represents millions more individuals than those exposed during early childhood. In this study, isoflurane exposure within a well-characterized adolescent period in Sprague-Dawley rats elicited immediate and persistent anxiety- and impulsive-like responding, as well as delayed cognitive impairment into adulthood. These behavioral abnormalities were paralleled by atypical dendritic spine morphology in the prefrontal cortex (PFC) and hippocampus (HPC), suggesting delayed anatomical maturation, and shifts in inhibitory function that suggest hypermaturation of extrasynaptic GABA(A) receptor inhibition. Preventing this hypermaturation of extrasynaptic GABA(A) receptor-mediated function in the PFC selectively reversed enhanced impulsivity resulting from adolescent isoflurane exposure. Taken together, these data demonstrate that the developmental window for susceptibility to enduring untoward effects of general anesthetics may be much longer than previously appreciated, and those effects may include affective behaviors in addition to cognition. |
| Databáze: | OpenAIRE |
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