Impaired colon microbiome and its correction in patients with juvenile rheumatoid arthritis
| Autor: | Yu.I. Bondarets, V.V. Berezhniy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Constipation Gastroenterology children juvenile rheumatoid arthritis Internal medicine medicine Large intestine synbiotic drug Gastrointestinal tract biology business.industry lcsh:RJ1-570 lcsh:Pediatrics dysbiosis medicine.disease biology.organism_classification colon microbiocenosis medicine.anatomical_structure Rheumatoid arthritis medicine.symptom Flatulence business Dysbiosis Juvenile rheumatoid arthritis Enterococcus faecium |
| Zdroj: | Sovremennaâ Pediatriâ, Iss 2(98), Pp 76-84 (2019) |
| ISSN: | 2412-4508 1992-5913 |
| DOI: | 10.15574/sp.2019.98.76 |
| Popis: | Objective: to investigate the state of the colon microbiota in patients with juvenile rheumatoid arthritis (JRA) against the background of treatment with basic, biological disease+modifying drugs and to evaluate the effectiveness of the combined synbiotic preparation (Rotabiotic) with the revealed violations. Materials and methods. In total of 29 children aged 1.5 to 16 years old were diagnosed with juvenile rheumatoid arthritis. A general clinical, instrumental examination was performed in accordance with a unified clinical protocol of medical care for children suffering from juvenile rheumatoid arthritis (Ministry of Health Order No. 832 of October 22, 2012). In addition, all children underwent bacteriological examination of feces before and after the identified violations of the intestinal microbiota. Results. When examining the gastrointestinal tract in patients with rheumatoid arthritis, there were complaints: intermittent abdominal pain in 23 (79.31%), loss of appetite — in 20 (68.97%), flatulence — in 12 (41.38%) , tendency to constipation — in 10 (34.48%) children. A violation of the microbiocenosis was found in 23 patients by reducing lactic and bifidobacteria of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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