Suprachoroidal Space Alterations Following Delivery of Triamcinolone Acetonide: Post-Hoc Analysis of the Phase 1/2 HULK Study of Patients With Diabetic Macular Edema
| Autor: | Charles C. Wykoff, David M. Brown, Shaun I.R. Lampen, Glenn Noronha, Rahul N. Khurana |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Visual acuity Triamcinolone acetonide genetic structures Diabetic macular edema Visual Acuity Triamcinolone Acetonide Macular Edema 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Suprachoroidal space Ophthalmology Post-hoc analysis Humans Medicine Prospective Studies Injectable Suspension Glucocorticoids Aged Retina Diabetic Retinopathy medicine.diagnostic_test Choroid business.industry Middle Aged eye diseases Treatment Outcome 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry Female sense organs medicine.symptom business Tomography Optical Coherence Follow-Up Studies medicine.drug |
| Zdroj: | Ophthalmic Surgery, Lasers and Imaging Retina. 49:692-697 |
| ISSN: | 2325-8179 2325-8160 |
| DOI: | 10.3928/23258160-20180831-07 |
| Popis: | BACKGROUND AND OBJECTIVE: To study anatomic changes in the suprachoroidal space (SCS) following suprachoroidal injection of CLS-TA, triamcinolone acetonide injectable suspension. PATIENTS AND METHODS: Eyes with diabetic macular edema receiving CLS-TA were imaged serially using anterior segment spectral-domain optical coherence tomography to examine the SCS. RESULTS: At the final imaging session, the SCS was not significantly different in study eyes (n = 14; 8.4 μm) compared to fellow eyes (n = 10; 8.1 μm; P = .698). Two eyes were imaged immediately before and 30 minutes after suprachoroidal injections; in these eyes, mean suprachoroidal width increased significantly following CLS-TA injection, 9.9 μm to 75.1 μm ( P < .001), and subsequently returned to 14.9 μm 1 month after the final injection ( P = .221). CONCLUSION: Suprachoroidal CLS-TA injection caused a measurable increase in the SCS, which returned to preinjection levels by 1 month following injection with no apparent lasting impact on SCS anatomy. [ Ophthalmic Surg Lasers Imaging Retina . 2018;49:692–697.] |
| Databáze: | OpenAIRE |
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