Pressure Oscillation Amplitude after Interruption of Tidal Breathing as an Index of Change in Airway Mechanics in Preschool Children
| Autor: | Sheila A. McKenzie, David Wertheim, Andrew C. Jackson, P.D. Bridge |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Pediatrics medicine.drug_class Coefficient of variation Respiratory physiology Asymptomatic Standard deviation Airway resistance Bronchodilator Internal medicine Pressure Humans Medicine Albuterol Diagnosis Computer-Assisted business.industry Airway Resistance Interrupter Technique Asthma Bronchodilator Agents Respiratory Function Tests Amplitude Child Preschool Pediatrics Perinatology and Child Health Respiratory Mechanics Cardiology Female medicine.symptom business |
| Zdroj: | Pediatric Pulmonology. 40:420-425 |
| ISSN: | 1099-0496 8755-6863 |
| DOI: | 10.1002/ppul.20267 |
| Popis: | Bronchodilator reversibility testing using change in airway resistance during interruption (Rint) is feasible in preschool children. Analysis of postocclusion oscillations of the mouth pressure-time transient (Pmo(t)), recorded during airflow interruption, may offer an alternative index of change in airway mechanics. We analyzed Pmo(t) oscillation amplitude in three different ways: 1) difference between the first relative maximum and minimum (AMxMn); 2) detection of the dominant frequency using Fourier analysis (AFS); and 3) curve-fitting based on a mathematical model (ACurv). In 25 asymptomatic asthmatic children, aged 2.5-5.6 years, who had undertaken reversibility testing, the correlation coefficients between baseline Rint and amplitude were: AMxMn r = -0.84, AFS r = -0.82, ACurv r = -0.84. The coefficient of variation (CoV) of readings contributing to baseline Rint measurement, as median (range), was 12% (5-24%), which was not significantly different from AFS or ACurv (P > 0.05). All parameters were significantly different postbronchodilator (P < 0.001). Using the sensitivity index, i.e., the change after intervention divided by the baseline standard deviation, ACurv was the most sensitive and Rint the least sensitive, with median (range) at 2.72 (-0.84 to 12.10) and 1.91 (-1.17 to 9.50), respectively (P = 0.005). Our results suggest that oscillation amplitude analysis may provide a sensitive index of change in airway mechanics in preschool children undertaking bronchodilator reversibility testing. |
| Databáze: | OpenAIRE |
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