Reperfusing the myocardium - a damocles Sword
| Autor: | V.K. Shah, K.K. Shalia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Diagnostic Imaging
RD1-811 Ischemic myocardium Ischemia Myocardial Reperfusion Myocardial Reperfusion Injury Review Article 030204 cardiovascular system & hematology No-reflow 03 medical and health sciences 0302 clinical medicine medicine Diseases of the circulatory (Cardiovascular) system Animals Humans Aspiration thrombectomy Myocytes Cardiac 030212 general & internal medicine Myocardial stunning business.industry Blood flow medicine.disease Microvascular obstruction Pharmacological conditioning Pathophysiology Clinical trial Tissue ischemia Anesthesia RC666-701 Surgery Ischemic conditioning Cardiology and Cardiovascular Medicine business Reperfusion injury |
| Zdroj: | Indian Heart Journal Indian Heart Journal, Vol 70, Iss 3, Pp 433-438 (2018) |
| ISSN: | 0019-4832 |
| Popis: | Return of blood flow after periodic ischemia is often accompanied by myocardial injury, commonly known as lethal reperfusion injury (RI). Experimental studies have shown that 50% of muscle die of ischemia and another 50% die because of reperfusion. It is characterized by myocardial, vascular, or electrophysiological dysfunction that is induced by the restoration of blood flow to previously ischemic tissue. This phenomenon reduces the efficiency of the present modalities used to combat the ischemic myocardium. Moreover, despite an improved understanding of the pathophysiology of this process and encouraging preclinical trials of multiple agents, most of the clinical trials to prevent RI have been disappointing and leaves us at ground zero to explore newer approaches. Keywords: Microvascular obstruction, No-reflow, Myocardial stunning, Aspiration thrombectomy, Ischemic conditioning, Pharmacological conditioning |
| Databáze: | OpenAIRE |
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