Perfluoroalkyl substances, thyroid hormones, and neuropsychological status in older adults

Autor: Srishti Shrestha, Michael S. Bloom, Richard F. Seegal, Edward F. Fitzgerald, Robert Rej, Qian Wu, Recai M. Yucel, Kurunthachalam Kannan, Robert J. McCaffrey
Rok vydání: 2017
Předmět:
Male
Mediation (statistics)
Wechsler Memory Scale
medicine.medical_specialty
Thyrotropin
Physiology
Neuropsychological Tests
010501 environmental sciences
01 natural sciences
Executive Function
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Wisconsin Card Sorting Test
Internal medicine
Reaction Time
medicine
Humans
Learning
Attention
Aged
0105 earth and related environmental sciences
Fluorocarbons
California Verbal Learning Test
medicine.diagnostic_test
business.industry
Public Health
Environmental and Occupational Health
Neuropsychology
Neuropsychological test
Middle Aged
Thyroxine
Perfluorooctane
Endocrinology
Alkanesulfonic Acids
chemistry
Perfluorooctanoic acid
Environmental Pollutants
Female
Caprylates
business
030217 neurology & neurosurgery
Environmental Monitoring
Zdroj: International Journal of Hygiene and Environmental Health. 220:679-685
ISSN: 1438-4639
DOI: 10.1016/j.ijheh.2016.12.013
Popis: Minimal data exist regarding the neurotoxicity of perfluoroalkyl substances (PFASs) in aging populations and the possible mediating effects of thyroid hormones (THs). Hence, the aims of this study were to: (i) assess associations between PFASs and neuropsychological function, and (ii) determine if such associations are mediated by changes in circulating THs in an aging population. We measured perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), total thyroxine (T4) and free thyroxine (fT4) in serum and performed neuropsychological tests in 126 men and women aged 55-74 years and living in upper Hudson River communities. Multivariable linear regressions were conducted to assess associations between PFASs and neuropsychological test scores. Mediation analyses were performed in a subset of 87 participants for whom information was available on both PFASs and THs. We calculated TH-mediated, non-TH mediated, and total effects of PFASs on neuropsychological test scores. Higher PFOA was associated with better performance in tasks of the California Verbal Learning Test and the Wisconsin Card Sorting Test. Higher PFOS was associated with improved performance in a Wechsler Memory Scale subtest and Block Design Subtest (BDT) total scores. There was no evidence of mediation by THs for PFOA-neuropsychological function associations. However, T4 and fT4 partially mediated the protective effect of PFOS on BDT total scores. Our findings do not suggest that PFASs are associated with poor neuropsychological function. There was some evidence of mediation for the association between PFASs and neuropsychological functions by THs, although some other modes of action also appear likely.
Databáze: OpenAIRE
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