Genetic diversity and antibiotic resistance inShigella dysenteriaeandShigella boydiistrains isolated from children aged <5 years in Egypt
| Autor: | M. A. Weiner, A. M. El-Gendy, Nasr El-Sayed, A. Mansour, A. W. Armstrong, John D. Klena, Sylvia Y. N. Young, Guillermo Pimentel |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Serotype Shigella boydii Shigella dysenteriae Sulfamethoxazole Epidemiology Drug resistance beta-Lactams medicine.disease_cause Polymerase Chain Reaction Microbiology Feces Antibiotic resistance Drug Resistance Bacterial medicine Humans Shigella Phylogeny Dysentery Bacillary biology Infant Newborn Infant biology.organism_classification Trimethoprim Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Infectious Diseases Child Preschool Egypt Female medicine.drug |
| Zdroj: | Epidemiology and Infection. 140:299-310 |
| ISSN: | 1469-4409 0950-2688 |
| Popis: | SUMMARYDiversity withinShigella dysenteriae(n=40) andShigella boydii(n=30) isolates from children living in Egypt aged Shigella-associated diarrhoea occurred mainly in summer months and in children aged S. dysenteriaeisolates; 50% ofS. boydiiisolates were serotype 2.S. dysenteriaeandS. boydiiisolates were often resistant to ampicillin, chloramphenicol and tetracycline (42%, 17%, respectively), although resistance varied among serotypes. Pulsed-field gel electrophoresis separated the isolates into distinct clusters correlating with species and serotype. Genetic differences in trimethoprim/sulfamethoxazole and β-lactam-encoding resistance genes were also evident.S. dysenteriaeandS. boydiiare genetically diverse pathogens in Egypt; the high level of multidrug resistance associated with both pathogens and resistance to the most available inexpensive antibiotics underlines the importance of continuing surveillance. |
| Databáze: | OpenAIRE |
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