Biomarkers in traumatic brain injury: new concepts
Autor: | Stefan Strilciuc, Dafin F. Muresanu, Ioana Chirila, Iulia Dobra, Pieter E. Vos, Nicoleta Jemna, Olivia Verisezan Rosu, Codruta Birle, Dana Slavoaca |
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Rok vydání: | 2020 |
Předmět: |
Adult
medicine.medical_specialty Neurology Traumatic brain injury medicine.medical_treatment Dermatology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Brain Injuries Traumatic Animals Humans Medicine 030212 general & internal medicine Intensive care medicine Neuroradiology Rehabilitation business.industry Surrogate endpoint Brain General Medicine Prognosis medicine.disease Psychiatry and Mental health Brain Injuries Neurology (clinical) Neurosurgery business Biomarkers 030217 neurology & neurosurgery Treatment monitoring |
Zdroj: | Neurological Sciences. 41:2033-2044 |
ISSN: | 1590-3478 1590-1874 |
Popis: | Traumatic brain injury is a multifaceted condition that encompasses a spectrum of injuries: contusions, axonal injuries in specific brain regions, edema, and hemorrhage. Brain injury determines a broad clinical and disability spectrum due to the implication of various cellular pathways, genetic phenotypes, and environmental factors. It is challenging to predict patient outcomes, to appropriately evaluate the patients, to determine a suitable treatment strategy and rehabilitation program, and to communicate with patient relatives. Biomarkers detected from body fluids are potential evaluation tools for traumatic brain injury patients. These may serve as internal indicators of cerebral damage, delivering valuable information about the dynamic cellular, biochemical, and molecular environments. The diagnostic and prognostic value of biomarkers tested both in animal models of traumatic brain injury is still under question, despite a considerable scientific literature. Recent publications emphasize that a more realistic approach involves combining multiple types of biomarkers with other investigative tools (imaging, outcome scales, and genetic polymorphisms). Additionally, there is increasing interest in the use of biomarkers as tools for treatment monitoring and as surrogate outcome variables to facilitate the design of distinct randomized controlled trials. This review highlights the latest available evidence regarding biomarkers in adults after traumatic brain injury and discusses new approaches in the evaluation of this patient group. |
Databáze: | OpenAIRE |
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