Impact of erythropoietin and myoinositol versus metformin on insulin resistance in a rat model of polycystic ovary syndrome
Autor: | Amany Abdelrahman, Aida A. Mahmoud, Nesreen G. Abd Elhaliem, Hassan Elalaf, Youstina Lamie Fanous |
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Rok vydání: | 2021 |
Předmět: |
Estrous cycle
medicine.medical_specialty endocrine system diseases Physiology business.industry Letrozole Insulin medicine.medical_treatment General Medicine medicine.disease Polycystic ovary Metformin Endocrinology Insulin resistance Erythropoietin Physiology (medical) Internal medicine Medicine business medicine.drug Hormone |
DOI: | 10.6084/m9.figshare.15046516.v1 |
Popis: | This study aimed to evaluate the therapeutic role of erythropoietin (EPO) or myoinositol versus metformin (MET) in improving the reproductive functions and glucose tolerance in a rat model of polycystic ovary (PCOS). Oral letrozole (LTZ) was used for induction of PCOS in wester rats for 21 days, after that, MET, EPO and myoinositol were administered for the following 21 days. The LTZ-induced PCOS rats have lost their oestrous cyclicity and become fixed at the diestrus phase, developed insulin resistance, abnormal sex and gonadotrophin hormone serum levels, increased cystic follicles, decreased number of the growing follicles and very little or no corpora lutea on microscopic examination, which were reversed by the three drugs, MET, EPO and myoinositol. MET and myoinositol were mostly equally effective in improving the reproductive manifestations of the disease. However, EPO was most effective in decreasing the insulin level observed in this LTZ-induced model of PCOS. |
Databáze: | OpenAIRE |
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