Antibacterial and in vivo reactivity of bioactive glass and poly(vinyl alcohol) composites prepared by melting and sol-gel techniques

Autor: Khansa Chaabouni, Tahia Boudawara, Salha Boulila, Fatma Makni-Ayedi, Abdelfattah Elfeki, Bertrand Lefeuvre, Rim Kallel, Amany A. Mostafa, Hassane Oudadesse, Mostafa Mabrouk, Hafed Elfeki, Slim Tounsi, Dhekra Mhalla, Allal Barroug
Přispěvatelé: Faculté des Sciences de Sfax, Université de Sfax - University of Sfax, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Biopesticides, Centre de Biotechnologie de Sfax (CBS), Université Cadi Ayyad [Marrakech] (UCA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Korean Journal of Chemical Engineering
Korean Journal of Chemical Engineering, Springer, 2016, 33 (5), pp.1659-1668. ⟨10.1007/s11814-015-0298-1⟩
Korean Journal of Chemical Engineering, 2016, 33 (5), pp.1659-1668. ⟨10.1007/s11814-015-0298-1⟩
ISSN: 0256-1115
1975-7220
DOI: 10.1007/s11814-015-0298-1⟩
Popis: International audience; Bioactive glass particle is used in the repair of bone defects. This material undergoes a series of surface in vivo reactions, which leads to osteointegration. We evaluated the effect of the bioactive glass synthesis, sol-gel (BG(S)) versus melting (BG(M)), associated with polyvinyl-alcohol (PVA) on in vivo bioactivity with biochemical parameters, liver-kidney histological structure and antibacterial in vitro activity. These composites were testified in many bacteria and implanted in ovariectomized rat. The serum and organs (liver and kidney) of all groups, control and treated rats, were collected to investigate the side effects of our composites, BG(S)-PVA and BG(M)-PVA, in comparison with control and ovariectomized rats. Also, the implants, before and after implantation, were prepared for analysis using physicochemical techniques such as Fourier transform infrared spectroscopy and X-ray diffraction. Our results have shown the stability of natremia, kaliemia, calcemia and phosphoremia. The histological structures of liver and kidney in implanted rats are intact compared to control and ovariectomized rats. BG(S)-PVA is characterized by a higher antibacterial effect on negative and positive gram bacteria than BG(M)-PVA. The physicochemical results have confirmed a progressive degradation of BG(S)-PVA and BG(M)-PVA, while replacing the implant by an apatite layer. But this bioactivity of BG(S)-PVA is faster than BG(M)-PVA. We can therefore confirm, on the one hand, the biocompatibility of our two implants and, on the other hand, the beneficial effect of sol-gel synthesis technique versus melting, both on the antibacterial effect and on the rapid formation of layer hydroxyapatite, and consequently on osteogenesis
Databáze: OpenAIRE
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