A Curriculum Vitae of Teeth: Evolution, Generation, Regeneration
| Autor: | Lukas H. Margaritis, Stauros Koussoulakos, Despina S. Koussoulakou |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
epithelial-mesenchymal interactions
Fibroblast Growth Factor 8 Ectomesenchyme Morphogenesis Review Bone Morphogenetic Protein 4 Biology Applied Microbiology and Biotechnology teeth evolution Epithelium stomatognathic system biology.animal Oral and maxillofacial pathology medicine Animals Humans Regeneration Molecular Biology development and regeneration Ecology Evolution Behavior and Systematics Cell Proliferation Mouth Dentition Regeneration (biology) Vertebrate Mesenchymal Stem Cells Cell Biology Anatomy medicine.disease Biological Evolution Natural position Odontogenic stomatognathic diseases Phenotype Tooth Diseases Evolutionary biology Mutation Odontogenesis Tooth Developmental Biology |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| DOI: | 10.7150/ijbs.5.226 |
| Popis: | The ancestor of recent vertebrate teeth was a tooth-like structure on the outer body surface of jawless fishes. Over the course of 500,000,000 years of evolution, many of those structures migrated into the mouth cavity. In addition, the total number of teeth per dentition generally decreased and teeth morphological complexity increased. Teeth form mainly on the jaws within the mouth cavity through mutual, delicate interactions between dental epithelium and oral ectomesenchyme. These interactions involve spatially restricted expression of several, teeth-related genes and the secretion of various transcription and signaling factors. Congenital disturbances in tooth formation, acquired dental diseases and odontogenic tumors affect millions of people and rank human oral pathology as the second most frequent clinical problem. On the basis of substantial experimental evidence and advances in bioengineering, many scientists strongly believe that a deep knowledge of the evolutionary relationships and the cellular and molecular mechanisms regulating the morphogenesis of a given tooth in its natural position, in vivo, will be useful in the near future to prevent and treat teeth pathologies and malformations and for in vitro and in vivo teeth tissue regeneration. |
| Databáze: | OpenAIRE |
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