Increased apoptosis level in late stages of rheumatoid arthritis correlates with macrophage number

Autor:	Sverker Lindblad, A-K Ulfgren, L Grondal, Lars Klareskog, A I Catrina
Rok vydání:	2001
Předmět:	medicine.medical_specialty business.industry Cell Dose dependence medicine.disease Chronic inflammatory disease Rheumatology In vitro medicine.anatomical_structure Apoptosis Internal medicine Rheumatoid arthritis Meeting Abstract Immunology medicine business Infiltration (medical)
Zdroj:	Arthritis Research Europe PubMed Central
ISSN:	1478-6362
DOI:	10.1186/ar280
Popis:	Rheumatoid arthritis (RA is a chronic inflammatory disease characterized by synovial hyperplasia and excessive mononuclear infiltration. Altered apoptosis was proposed as a possible mechanism for cell accumulation. In vitro experiments showed that monokines are able to inhibit synovial apoptosis in a dose dependent manner. In this study we aim to investigate synovial apoptosis with respect to disease duration, inflammatory cell type and monokines expression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857408ae187f45dd29c692a63136fbe6 https://doi.org/10.1186/ar280 Zobrazit plný text záznamu Full text from SpringerLink