Activations in gray and white matter are modulated by uni-manual responses during within and inter-hemispheric transfer: effects of response hand and right-handedness
| Autor: | Paolo Brambilla, Vaibhav A. Diwadkar, Asadur Chowdury, Cinzia Perlini, Franco Alessandrini, Carlo Alberto Marzi, A. Carlo Altamura, Veronica Marinelli, Gianluca Rambaldelli, Silvia Savazzi, Marcella Bellani, Mirella Ruggieri, Giada Zoccatelli, Elisa Ciceri |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cognitive Neuroscience Poffenberger paradigm Transfer Psychology Article 050105 experimental psychology Functional Laterality Motor organization Right handedness White matter 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience Young Adult 0302 clinical medicine Motor system medicine Inter-hemispheric transfer Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Gray Matter Brain Mapping Neuronal Plasticity 05 social sciences Right-handedness fMRI Neuropsychology Brain Hand Magnetic Resonance Imaging White Matter Hand dominance Psychiatry and Mental health Visual cortex medicine.anatomical_structure Neurology Female Neurology (clinical) Psychology Neuroscience Gray (horse) 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Brain imaging and behavior. 12(4) |
| ISSN: | 1931-7565 |
| Popis: | Because the visual cortices are contra-laterally organized, inter-hemispheric transfer tasks have been used to behaviorally probe how information briefly presented to one hemisphere of the visual cortex is integrated with responses resulting from the ipsi- or contra-lateral motor cortex. By forcing rapid information exchange across diverse regions, these tasks robustly activate not only gray matter regions, but also white matter tracts. It is likely that the response hand itself (dominant or non-dominant) modulates gray and white matter activations during within and inter-hemispheric transfer. Yet the role of uni-manual responses and/or right hand dominance in modulating brain activations during such basic tasks is unclear. Here we investigated how uni-manual responses with either hand modulated activations during a basic visuo-motor task (the established Poffenberger paradigm) alternating between inter- and within-hemispheric transfer conditions. In a large sample of strongly right-handed adults (n=49), we used a factorial combination of transfer condition [Inter vs. Within] and response hand [Dominant(Right) vs. Non-Dominant (Left)] to discover fMRI-based activations in gray matter, and in narrowly defined white matter tracts. These tracts were identified using a priori probabilistic white matter atlases. Uni-manual responses with the right hand strongly modulated activations in gray matter, and notably in white matter. Furthermore, when responding with the left hand, activations during inter-hemispheric transfer were strongly predicted by the degree of right-hand dominance, with increased right-handedness predicting decreased fMRI activation. Finally, increasing age within the middle-aged sample was associated with a decrease in activations. These results provide novel evidence of complex relationships between uni-manual responses in right-handed subjects, and activations during within- and inter-hemispheric transfer. The results suggest that the organization of the motor system exerts sophisticated functional effects. Moreover, our evidence of activation in white matter tracts is consistent with prior studies, confirming fMRI-detectable white matter activations which are systematically modulated by experimental condition. |
| Databáze: | OpenAIRE |
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