Role of CD4 + and CD8 + T Cells in Clearance of Primary Pulmonary Infection with Coxiella burnetii
| Autor: | Amanda Read, Allen G. Harmsen, Sara Erickson |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Immunology Spleen Inflammation Mice SCID CD8-Positive T-Lymphocytes Microbiology Mice Immune system Immunity Pneumonia Bacterial medicine Animals Cytotoxic T cell Lung Immunity Cellular Mice Inbred BALB C biology Coxiella burnetii biology.organism_classification Primary adaptive immune response Virology Infectious Diseases medicine.anatomical_structure Microbial Immunity and Vaccines Parasitology medicine.symptom Q Fever CD8 |
| Zdroj: | Infection and Immunity. 78:3019-3026 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.00101-10 |
| Popis: | The mechanisms of the primary adaptive immune response to Coxiella burnetii are not well known. Following inoculation of the lungs with C. burnetii Nine Mile phase I (NMI), SCID mice developed pneumonia and splenomegaly and succumbed to infection, whereas wild-type mice cleared the infection by 24 days. SCID mice reconstituted with either CD4 + T cells or CD8 + T cells alone were able to control the infection, indicating that the presence of either type of T cells was sufficient to control infection, and B cells were not necessary for primary immunity. Similarly, wild-type mice depleted of either CD4 + T cells or CD8 + T cells controlled infections in their lungs, but these mice were highly susceptible if they were depleted of both types of T cells. However, compared to CD4 + T-cell-dependent protection, CD8 + T-cell-dependent protection resulted in less inflammation in the lungs and less growth of bacteria in the spleens. |
| Databáze: | OpenAIRE |
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