CASP9 c.-1339AG and CASP3 c.-1191AG polymorphisms alter susceptibility and clinical aspects of head and neck squamous cell carcinoma
| Autor: | Ericka Francislaine Dias Costa, Guilherme Silva Nogueira, Carmen Silvia Passos Lima, Tathiane Regine Penna Lima, José Augusto Rinck-Junior, Gustavo Jacob Lourenço, Leisa Lopes-Aguiar |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Genotype Single-nucleotide polymorphism Kaplan-Meier Estimate Polymorphism Single Nucleotide law.invention 03 medical and health sciences Young Adult 0302 clinical medicine law Medicine Humans Genetic Predisposition to Disease Genotyping Gene Laryngeal Neoplasms Polymerase chain reaction Aged Aged 80 and over Chi-Square Distribution business.industry Caspase 3 Squamous Cell Carcinoma of Head and Neck Intrinsic apoptosis Pharyngeal Neoplasms Middle Aged medicine.disease Head and neck squamous-cell carcinoma Caspase 9 stomatognathic diseases 030104 developmental biology Otorhinolaryngology Apoptosis 030220 oncology & carcinogenesis Case-Control Studies Cancer research Female Mouth Neoplasms business |
| Zdroj: | Headneck. 41(8) |
| ISSN: | 1097-0347 |
| Popis: | Background Single nucleotide polymorphisms (SNPs) in genes that act in intrinsic apoptosis pathway may modulate cancer susceptibility. This study investigated the roles of CASP9 c.-1339A>G (rs4645978) and CASP3 c.-1191A>G (rs12108497) SNPs on risk and behavior of head and neck (HN) squamous cell carcinoma (SCC). Methods DNA of 350 patients with HNSCC and 350 controls was analyzed by polymerase chain reaction method for genotyping. Results CASP3 c.-1191AG or GG genotype was more common in patients with HNSCC and oral cavity or oropharynx SCC than in controls; carriers of this genotype were under 2.15 and 2.81-fold increased risks of the respective tumors. CASP9 c.-1339AG or GG plus CASP3 c.-1191AG or GG genotypes were associated with oral cavity or oropharynx SCC early onset. Conclusion These findings present, for the first time, preliminary evidence that inherited abnormalities related to CASP9 c.-1339A>G and CASP3 c.-1191A>G SNPs are determinants of HNSCC risk and clinical aspects. |
| Databáze: | OpenAIRE |
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