Tunable oscillations in the Purkinje neuron
| Autor: | Dirk Trauner, Yuan Wang, Ajithkumar Warrier, Xiang Zhang, Ze'ev R. Abrams |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Functional role
Cerebellum Quantitative Biology::Tissues and Organs Models Neurological FOS: Physical sciences Action Potentials Dynamic control Purkinje neuron 03 medical and health sciences Purkinje Cells 0302 clinical medicine Control theory Biological Clocks medicine Animals Humans Computer Simulation Physics - Biological Physics 030304 developmental biology Physics 0303 health sciences Quantitative Biology::Neurons and Cognition Oscillation medicine.anatomical_structure nervous system Biological Physics (physics.bio-ph) Parametric oscillator Forced oscillation Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Physical review. E, Statistical, nonlinear, and soft matter physics. 85(4 Pt 1) |
| ISSN: | 1550-2376 |
| Popis: | In this paper, we study the dynamics of slow oscillations in Purkinje neurons in vitro, and derive a strong association with a forced parametric oscillator model. We demonstrate the precise rhythmicity of the oscillations in Purkinje neurons, as well as a dynamic tunability of this oscillation using a photo-switchable compound. We show that this slow oscillation can be induced in every Purkinje neuron, having periods ranging between 10-25 seconds. Starting from a Hodgkin-Huxley model, we also demonstrate that this oscillation can be externally modulated, and that the neurons will return to their intrinsic firing frequency after the forced oscillation is concluded. These results signify an additional functional role of tunable oscillations within the cerebellum, as well as a dynamic control of a time scale in the brain in the range of seconds. 12 pages, 5 figures |
| Databáze: | OpenAIRE |
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