Localization of monoamine oxidase of type A and B in blood vessels with different innervation patterns
| Autor: | M M Caramona |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Serotonin
medicine.medical_specialty Human ear Monoamine oxidase Adrenergic Endogeny Norepinephrine Dogs medicine.artery Internal medicine medicine Animals Humans Vein Monoamine Oxidase Pharmacology business.industry Phosphate buffered saline Umbilical artery General Medicine Anatomy medicine.anatomical_structure Endocrinology Blood Vessels Rabbits business Artery |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 324:185-189 |
| ISSN: | 1432-1912 0028-1298 |
| DOI: | 10.1007/bf00503892 |
| Popis: | Homogenates of dog mesenteric artery, dog saphenous vein, denervated saphenous vein, rabbit ear artery, denervated ear artery and human umbilical artery were prepared in phosphate buffer. Monoamine oxidase activity was determined with [3H]-5-hydroxytryptamine ([3H]-5-HT) as a preferential substrate for MAO type A and [14C]-beta-phenylethylamine as a preferential substrate for MAO type B. The endogenous noradrenaline content was compared with the MAO activities in these blood vessels. The results show that there is a good relationship of MAO type A content with the density of adrenergic innervation, but it is evident that this type of MAO is present even in vessels devoid of adrenergic innervation. Thus, MAO type A in these vascular structures has both intraneuronal and extraneuronal locations whereas MAO type B is predominantly or exclusively extraneuronal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink