Protective impact of N-acetyl-L-cysteine on methionine stimulatory effects in rat colon
| Autor: | Lara Hadži-Tanović, Dragan Đurić, Marija Stojanović, Ljiljana Šćepanović, Dušan Todorović |
|---|---|
| Jazyk: | srbština |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Muscularis mucosae Antioxidant Computer Networks and Communications medicine.medical_treatment N-group (finite group theory) Crypt lcsh:Medicine 030204 cardiovascular system & hematology Biology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine N-acetyl-L-cysteine medicine rat 2. Zero hunger methionine Lamina propria Methionine colon lcsh:R 3. Good health medicine.anatomical_structure Endocrinology chemistry Hardware and Architecture Colon disorder Software Oxidative stress 030215 immunology |
| Zdroj: | Medicinski podmladak (2016) 67(2):80-84 Medicinski Podmladak, Vol 67, Iss 2, Pp 80-84 (2016) |
| ISSN: | 0369-1527 |
| Popis: | Introduction: Methionine is an essential sulfuric amino acid, which, according to numerous studies, has a role in the reduction of inflammation, caused by changes in colon, and inhibits important pathways in the development of numerous gastrointestinal disorders. However, subchronic methionine loading leads to oxidative stress, which is a potential cause of disease of numerous organs, digestive tract being one of them. N-acetyl-L-cysteine is a natural antioxidant, which affects some of the important signaling pathways and has a potential therapeutic role in treatment of colon disorders. Aim: To examine the influence of N-acetyl-L-cysteine on histological parameters of rat colon, after subchronic methionine load. Material and methods: Experiments were conducted on 15-20 days old male (Wistar albino) rats, weighing 160 g. There were used 24 animals in the experiment, divided into 3 groups, with eight animals per group. First, control group (K), received NaCl, second group received methionine (M group), while third group received methionine + N-acetyl-L-cysteine (N group). The rats were sacrificed after 21 day and tissue samples of colon were obtained. In all of the three groups, changes of histological parameters of rat colon were analyzed. Results: Methionine load leads to statistically significant increase (p < 0.01) in crypt depth of rat colon, lamina muscularis mucosae thickness, the mucosal thickness and increase in lamina propria cell density compared to control, while N-acetyl- L-cysteine application showed statistically significant decrease (p < 0.01) of these histological parameters compared to M group. Conclusion: N-acetyl-L-cysteine has a significantly protective effect on methionine load induced changes in rat colon. |
| Databáze: | OpenAIRE |
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