Environmental Risk Factors for Progressive Supranuclear Palsy
| Autor: | Park, Hee Kyung, Ilango, Sindana D., Litvan, Irene |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Neurology environmental exposure Neurosciences. Biological psychiatry. Neuropsychiatry Review Article Disease Neurodegenerative Progressive supranuclear palsy 03 medical and health sciences Rare Diseases 0302 clinical medicine Environmental risk Clinical Research 0502 economics and business medicine risk factors 2.1 Biological and endogenous factors RC346-429 Pediatric business.industry Prevention Parkinsonism 05 social sciences Neurosciences Cognition progressive supranuclear palsy Environmental exposure Perinatal Period - Conditions Originating in Perinatal Period medicine.disease eye diseases Supranuclear gaze palsy Brain Disorders Risk factors Neurological Neurology. Diseases of the nervous system Neurology (clinical) business 050203 business & management 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Journal of movement disorders, vol 14, iss 2 Journal of Movement Disorders, Vol 14, Iss 2, Pp 103-113 (2021) Journal of Movement Disorders |
| ISSN: | 2093-4939 2005-940X |
| Popis: | Typically, progressive supranuclear palsy (PSP) is clinically characterized by slow vertical saccades or supranuclear gaze palsy, levodopa-resistant parkinsonism with predominant axial symptoms, and cognitive executive impairment. Over the past decades, various PSP phenotypes, including PSP with predominant parkinsonism, PSP with corticobasal syndrome, PSP with progressive gait freezing, and PSP with predominant frontal dysfunction, have been identified from pathologically confirmed cases. Expanding knowledge led to new diagnostic criteria for PSP that with increased disease awareness led to increased PSP prevalence estimates. The identification of environmental and modifiable risk factors creates an opportunity to intervene and delay the onset of PSP or slow disease progression. To date, despite the increasing number of publications assessing risk factors for PSP, few articles have focused on environmental and lifestyle risk factors for this disorder. In this article, we reviewed the literature investigating the relationship between PSP and several environmental and other modifiable lifestyle risk factors. In our review, we found that exposures to toxins related to diet, metals, well water, and hypertension were associated with increased PSP risk. In contrast, higher education and statins may be protective. Further case-control studies are encouraged to determine the exact role of these factors in the etiopathogenesis of PSP, which in turn would inform strategies to prevent and reduce the burden of PSP. |
| Databáze: | OpenAIRE |
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