Neoadjuvant Chemotherapy for Ewing's Sarcoma of Bone in Patients Older than Thirty-nine Years: Experience of Twenty-three Cases at the Istituto Ortopedico Rizzoli

Autor:	Stefano Ferrari, Antonio Zanone, Alessandra Longhi, Pietro Ruggieri, Simonetta Rimondini, Cristiana Forni, Franco Bertoni, Gaetano Bacci, Michela Versari, Alessandro Comandone
Rok vydání:	2000
Předmět:	Chemotherapy medicine.medical_specialty business.industry medicine.medical_treatment Ewing's sarcoma Hematology General Medicine medicine.disease Surgery Radiation therapy Clinical trial Regimen Oncology El Niño medicine Radiology Nuclear Medicine and imaging Sarcoma business Cohort study
Zdroj:	Scopus-Elsevier
ISSN:	1651-226X 0284-186X
DOI:	10.1080/028418600431076
Popis:	The aim of this study was to determine whether the behaviour of Ewing's sarcoma of bone in adult patients is the same as that observed in children and adolescents. We reviewed the clinical features and outcomes of 23 patients over the age of 39 (17 males, 6 females) who had been treated with neoadjuvant chemotherapy between 1983 and 1995 at our institution. The most common primary sites of tumor were the extremities (16 cases); tumor volume was more than 100 ml in 17 patients, and elevated serum LDH levels were found in 6 cases. The local treatment was surgery in 8 cases, surgery plus radiotherapy in 8, and radiotherapy alone in 7 cases. Chemotherapy comprised a 4-drug regimen in 10 patients, while the other 13 patients received 6 drugs. At a follow-up of 8.8 years (3.5-15) 13 patients remained continuously free of disease and 10 relapsed. The 5-year disease-free survival and overall survival rates were 53% and 59%, respectively. Clinical features, dose intensity, and toxicity of chemotherapy, as well as ...
Databáze:	OpenAIRE
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