Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis

Autor: Eduardo Ferreira de Castro Neto, Joselita Ferreira Carvalho Santiago, Luís Otávio Sales Ferreira Caboclo, Mauro Canzian, Débora Amado, Elisa Mieko Suemitsu Higa, Ricardo Silva Centeno, Maria da Graça Naffah-Mazzacoratti, Elza Márcia Targas Yacubian, Pedro Paulo Vasconcellos Varella, Esper A. Cavalheiro, Henrique Carrete
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Pathology
Interleukin-1beta
Fluid-attenuated inversion recovery
Hippocampal formation
glutamate and hippocampal sclerosis
Hippocampus
chemistry.chemical_compound
Epilepsy
Hippocampus (mythology)
sinal hipocampal em FLAIR
Neurotransmitter
Glutamate receptor
Middle Aged
Amygdala
Magnetic Resonance Imaging
Temporal Lobe
Neurology
Female
esclerose hipocampal
Inflammation Mediators
medicine.symptom
psychological phenomena and processes
Adult
medicine.medical_specialty
Glutamic Acid
Inflammation
Nitric Oxide
Temporal lobe
lcsh:RC321-571
NO
Young Adult
medicine
Humans
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Sclerosis
FLAIR hippocampal signal
Tumor Necrosis Factor-alpha
business.industry
medicine.disease
cytokines
Epilepsy
Temporal Lobe
chemistry
glutamato
nervous system
citocinas
Leukocyte Common Antigens
Neurology (clinical)
business
Interleukin-1
Zdroj: Arquivos de Neuro-Psiquiatria v.69 n.1 2011
Arquivos de neuro-psiquiatria
Academia Brasileira de Neurologia
instacron:ABNEURO
Arquivos de Neuro-Psiquiatria, Vol 69, Iss 1, Pp 91-99 (2011)
Arquivos de Neuro-Psiquiatria, Volume: 69, Issue: 1, Pages: 91-99, Published: FEB 2011
Popis: We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p
Databáze: OpenAIRE
Externí odkaz: