Towards a Unified Model of SMC Complex Function
| Autor: | Christian H. Haering, Indra A. Shaltiel, Markus Hassler |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cohesin biology Chromosomal Proteins Non-Histone Condensin SMC protein Computational biology Chromatin Assembly and Disassembly Chromosomes Article General Biochemistry Genetics and Molecular Biology Molecular machine Chromatin Chromosome segregation Motor protein 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Multiprotein Complexes biology.protein Humans Carrier Proteins General Agricultural and Biological Sciences DNA |
| Zdroj: | Current Biology |
| ISSN: | 0960-9822 |
| Popis: | Protein complexes built of Structural Maintenance of Chromosomes (SMC) and kleisin subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of genome architecture in all kingdoms of life. How these large ring-shaped molecular machines use the energy of ATP hydrolysis to change the topology of chromatin fibers has remained a central unresolved question of chromosome biology. A currently emerging concept suggests that the common principle that underlies the essential functions of SMC protein complexes in the control of gene expression, chromosome segregation or DNA damage repair is their ability to expand DNA into large loop structures. Here, we review the current knowledge about the biochemical and structural properties of SMC proteins complexes that might allow them to accomplish DNA loop extrusion and compare their action to other motor proteins and nucleic acid translocases. We evaluate the currently predominant models of active loop extrusion and propose a detailed version of a ‘scrunching’ model, which reconciles much of the available mechanistic data and provides an elegant explanation for how SMC protein complexes fulfill an array of seemingly diverse tasks during the organization of genomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|