Preemptive Duloxetine Relieves Postoperative Pain and Lowers Wound Temperature in Centrally Sensitized Patients Undergoing Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial

Autor:	In Jun Koh, Dong Chul Park, Yong Gyu Sung, Jae Won Na, Man Soo Kim, Yong In
Rok vydání:	2021
Předmět:	total knee arthroplasty Central sensitization Visual analogue scale Total knee arthroplasty Placebo-controlled study wound healing Placebo Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Duloxetine pain Brief Pain Inventory Adverse effect 030203 arthritis & rheumatology 030222 orthopedics business.industry duloxetine central sensitization General Medicine chemistry randomized Anesthesia business
Zdroj:	Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 2809, p 2809 (2021) Volume 10 Issue 13
ISSN:	2077-0383
DOI:	10.3390/jcm10132809
Popis:	(1) Background: The purpose of this study was to determine whether preemptive duloxetine in patients with central sensitization (CS) is effective for acute postoperative pain control and wound healing following total knee arthroplasty (TKA). (2) Methods: CS was defined as a score of 40 points or higher on the Central Sensitization Inventory (CSI) survey. Thirty-nine patients with CS were randomly assigned to either the duloxetine group (n = 19) or the placebo group (n = 20). The duloxetine group took duloxetine 30 mg once a day, while the placebo group took the placebo medication once a day. A pain visual analog scale (VAS) and the Brief Pain Inventory (BPI), wound complications, the temperature of the surgical site, and adverse events were investigated. Skin temperature was measured at the center of the patella using a portable digital thermometer. (3) Results: The duloxetine group reported significantly lower pain VAS scores during follow-up periods up to 6 weeks after surgery (all p < 0.05). BPI interference also showed significantly superior results in the duloxetine group after surgery (all p < 0.05). Although there was no difference in the rate of wound complications between the two groups (p > 0.05), the duloxetine group showed significantly lower wound temperature than the placebo group during the follow-up period (all p < 0.05). (4) Conclusion: In this study, preemptive duloxetine effectively reduced pain and lowered wound temperature following TKA in CS patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849c253fe07506284c6bb79a95a921ca https://doi.org/10.3390/jcm10132809 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.