Genetic characterization of H5N1 influenza viruses isolated from chickens in Indonesia in 2010
| Autor: | Yoshihiro Kawaoka, Setyarina Indrasari, Kiyoko Iwatsuki Horimoto, Chairul A. Nidom, Shinya Yamada, Kadek Rahmawati, Reviany V. Nidom, Muhamad Y. Alamudi, Kholik, Ratnani S. Hayati |
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| Rok vydání: | 2012 |
| Předmět: |
Phylogenic analysis
medicine.medical_specialty Genotype viruses Molecular Sequence Data Hemagglutinin (influenza) medicine.disease_cause H5N1 genetic structure Article Medical microbiology Virology Genetics medicine Animals Cluster Analysis H5N1 influenza virus Clade Molecular Biology Phylogeny Poultry Diseases Influenza A Virus H5N1 Subtype biology Plant Sciences virus diseases Outbreak Sequence Analysis DNA General Medicine Influenza A virus subtype H5N1 Biomedicine Indonesia Medical Microbiology Influenza in Birds biology.protein RNA Viral Genetic characterization Chickens Neuraminidase |
| Zdroj: | Virus Genes |
| ISSN: | 1572-994X 0920-8569 |
| DOI: | 10.1007/s11262-012-0722-0 |
| Popis: | Since 2003, highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry in Indonesia every year, producing the highest number of human victims worldwide. However, little is known about the H5N1 influenza viruses that have been circulating there in recent years. We therefore conducted surveillance studies and isolated eight H5N1 viruses from chickens. Phylogenic analysis of their hemagglutinin and neuraminidase genes revealed that all eight viruses belonged to clade 2.1.3. However, on the basis of nucleotide differences, these viruses could be divided into two groups. Other viruses genetically closely related to these two groups of viruses were all Indonesian isolates, suggesting that these new isolates have been evolving within Indonesia. Among these viruses, two distinct viruses circulated in the Kalimantan islands during the same season in 2010. Our data reveal the continued evolution of H5N1 viruses in Indonesia. |
| Databáze: | OpenAIRE |
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