High HER-2 protein levels correlate with clinicopathological features in colorectal cancer

Autor: Xing-Yang Zhang, Yi-tong Guo, Ying Li, Zhi-Gang Tan, Qian Lin, Yan Song, Juan Li, Qiong Sun, Shengjie Sun
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Male
medicine.medical_specialty
Pathology
Colorectal cancer
Receptor
ErbB-2
lcsh:RC254-282
Correlation
03 medical and health sciences
0302 clinical medicine
Asian People
Internal medicine
medicine
Biomarkers
Tumor
Humans
Radiology
Nuclear Medicine and imaging
Clinicopathological features
colorectal cancer
disease-free survival
dukes stage
HER-2
lymph node metastasis
meta-analysis
prognosis
business.industry
General Medicine
Odds ratio
medicine.disease
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Confidence interval
Gene Expression Regulation
Neoplastic
030104 developmental biology
030220 oncology & carcinogenesis
Meta-analysis
Lymphatic Metastasis
Inclusion and exclusion criteria
Clinicopathological features
Female
business
HER-2 protein
Colorectal Neoplasms
Zdroj: Journal of Cancer Research and Therapeutics, Vol 12, Iss 1, Pp 323-333 (2016)
ISSN: 1998-4138
0973-1482
Popis: Aim: To obtain a correlation between HER-2 expression and the clinicopathological features incolorectal cancers. (CRCs) using a meta.analysis based approach. Materials and Methods: Electronic databases and reference lists were searched for relevant published studies. After inclusion and exclusion criteria were applied, case and control studies related to research topic were included in present meta-analysis. Data analysis was performed using Comprehensive Meta Analysis. (CMA) 2.0 software. Result: A total of 30 studies comprising 4,942 CRC patients and 521 healthy controls met the inclusion criteria. Our major results implied that the expression level of HER-2 was significantly higher in CRC patients than healthy controls (odds ratio (OR) = 10.436, 95% confidence interval (CI) = 5.498–19.810, P < 0.001). Sample stratification based on Dukes stages suggested that increased expression level of HER-2 protein was found in CRC patients with Dukes C/D compared with CRC patients with Dukes A/B (OR = 0.335, 95% CI = 0.198–0.568, P < 0.001). The current meta-analysis also found that, in CRC patients with lymph node metastasis (LNM), the HER-2 expression was significantly higher than that in CRC patients without LNM (OR = 1.987, 95%CI = 1.209–3.265, P = 0.007). Conclusion: Our meta-analysis study strongly suggests that HER-2 expression levels are clearly correlated with the clinicopathological features in CRC; therefore, HER-2 may be a potential biomarker for diagnosis and prognosis of CRC.
Databáze: OpenAIRE
Externí odkaz: