AEG -1 Overexpression: A Novel Indicator for Peritoneal Dissemination and Lymph Node Metastasis in Epithelial Ovarian Cancers
| Autor: | Yuan Zhang, Yulan Zhao, Xicai Sun, Junjun Liu, Ge Yu, Xiaochuan Wang, Xiaoguang Yu, Renbo Lu, Xiaoming Ning, Jingshu Geng, Ping Lin, Cong Li, Hongtao Song |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Oncology medicine.medical_specialty medicine.medical_treatment Disease Carcinoma Ovarian Epithelial Metastasis Internal medicine Biomarkers Tumor medicine Humans Neoplasms Glandular and Epithelial Survival rate Peritoneal Neoplasms Aged Aged 80 and over Ovarian Neoplasms Chemotherapy business.industry Membrane Proteins RNA-Binding Proteins Obstetrics and Gynecology Odds ratio Middle Aged Prognosis medicine.disease Up-Regulation Gene Expression Regulation Neoplastic Blot Lymphatic Metastasis Immunohistochemistry Female Lymph Nodes Ovarian cancer business Cell Adhesion Molecules |
| Zdroj: | International Journal of Gynecologic Cancer. 21:602-608 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1097/igc.0b013e3182145561 |
| Popis: | Objective:Despite advances in chemotherapy and cytoreductive surgery, ovarian cancer remains the most lethal gynecological malignancy with a 5-year survival rate of 25% to 30% in advanced stage disease. Our purpose is to evaluate whether astrocyte elevated gene-1 (AEG-1) is a novel predictor of peritoneal dissemination and lymph node metastasis in epithelial ovarian cancer (EOC), which was not previously studied by others.Materials and Methods:Through immunohistochemical and Western blot analysis, AEG-1 expression was evaluated in 25 normal ovarian and 157 EOC specimens. The relationship between AEG-1 expression and EOC metastasis was determined by univariate and multivariate analyses.Results:Western blotting analysis revealed that AEG-1 was overexpressed in metastatic tissues from patients with ovarian cancers. Immunohistochemistry results showed that 83 (95.4%) presented peritoneal dissemination; 41 (47.1%) had lymph node metastasis among 87 patients with AEG-1 overexpression. Univariate and multivariate logistic regression analyses demonstrated that AEG-1 overexpression correlated with peritoneal dissemination and lymph node metastasis in EOC. We further found that the positive and specificity predictive value of AEG-1 staining were better for peritoneal metastasis, whereas the negative and sensitivity predictive value of AEG-1 staining were better for lymph node metastasis. The odds ratio of high-to-low expression for peritoneal dissemination was 8.541 (95% confidence interval, 2.561-37.461), and that for lymph node metastasis was 9.581 (95% confidence interval, 2.613-23.214).Conclusions:The present findings indicate that AEG-1 is overexpressed in a great portion of EOC patients with peritoneal dissemination and/or lymph node metastasis and may be clinically useful for predicting metastasis in EOC. Our findings might provide some benefits for metastatic EOC patients in the clinic. |
| Databáze: | OpenAIRE |
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