Triggered doxorubicin release using redox-sensitive hyaluronic acid-g-stearic acid micelles for targeted cancer therapy
| Autor: | Gyeong-Won Jeong, Young-Il Jeong, Jae-Woon Nah |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
Nanoparticle Antineoplastic Agents 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Mice chemistry.chemical_compound In vivo Hyaluronic acid Materials Chemistry medicine Animals Humans Doxorubicin Hyaluronic Acid Micelles Drug Carriers Organic Chemistry Glutathione HCT116 Cells 021001 nanoscience & nanotechnology 0104 chemical sciences Drug Liberation chemistry Targeted drug delivery Biophysics Nanoparticles Stearic acid 0210 nano-technology Oxidation-Reduction Stearic Acids medicine.drug |
| Zdroj: | Carbohydrate Polymers. 209:161-171 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2019.01.018 |
| Popis: | To develop a carrier for targeted drug delivery and triggered drug release in a reducing-tumor environment, reduction-sensitive hyaluronic acid-g-stearic acid (HCS) micelles were synthesized using a coupling agent. The HCS 40% was shown to have a more compact particle size than HCS 20% and the particle size of doxorubicin (DOX)-loaded HCS (HCSD) was increased relative to that of HCS micelles. The behavior of DOX release from HCSD showed that DOX was rapidly released in GSH (10 mM) solution. The site-specific targeting effect of HCSD nanoparticles was investigated by cellular uptake and competition assay at HCT116 and CT26 cell lines. An in vivo study of HCSD revealed that tumor suppression and site-specific targeted delivery of HCSD nanoparticles in HCT116-xenografted tumors were more superb than in the CT26-xenografted tumor. These results suggest that HCSD nanoparticles can be expected to have high therapeutic efficacy because they enable targeted drug delivery and rapid drug release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect