Uterine Cytokine Profile in a Rat Model of Endometritis
| Autor: | Liqun Xue, Qing Yang, Zhonglin Xiao, Daojun Xu, Jun He, Qing Liao, Hailin Xiong, Naidong Wang |
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| Rok vydání: | 2014 |
| Předmět: |
Chemokine
medicine.medical_treatment Immunology Stimulation Disease Rats Sprague-Dawley medicine Animals Immunology and Allergy Escherichia coli Infections Acetic Acid biology Uterus Obstetrics and Gynecology Interleukin Uterine horns Staphylococcal Infections medicine.disease Rats Disease Models Animal Cytokine Reproductive Medicine CXCL5 biology.protein Cytokines Female Endometritis Inflammation Mediators |
| Zdroj: | American Journal of Reproductive Immunology. 73:214-220 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/aji.12330 |
| Popis: | Problem Endometritis is a common reproductive disorder in female domestic animals. Roles of cytokines and chemokines have been implicated in this disease. To date, no comprehensive panel of the cytokine profile in inflammatory sites of endometritis has been reported. Method of study To address cytokine profiles in endometritis, a bacteria-induced rat model of endometritis was developed and levels of 27 cytokines were measured in paired uterine horn tissues using a multiple cytokine array. Results Of the 27 cytokines, five pro-inflammatory mediators, including three cytokine-induced neutrophil chemo-attractant (CINC)-1, CINC-2 and CINC-3, interleukin (IL)-1a and CXC family member CXCL5/LIX were increased upon the stimulation of bacteria. Conclusions High expression of CINCs as well IL-1a and CXCL5/LIX suggests their potent roles in the pathogenicity of endometritis. |
| Databáze: | OpenAIRE |
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