Exercise-Induced Oxygen Desaturation as a Predictive Factor for Longitudinal Decline in 6-Minute Walk Distance in Subjects With COPD
| Autor: | Hideki Sakai, Yukari Fujimoto, Yutaro Oki, Akira Ishikawa, Shogo Misu, Rei Ono, Masahiro Kaneko |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Vital Capacity Walk Test Critical Care and Intensive Care Medicine Pulmonary Disease Chronic Obstructive 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Predictive Value of Tests Internal medicine Linear regression medicine Humans Longitudinal Studies Exercise Aged COPD Exercise Tolerance Oxygen desaturation medicine.diagnostic_test business.industry Confounding General Medicine Prognosis medicine.disease Predictive factor 030228 respiratory system Linear Models Female Observational study business 6 min walking test |
| Zdroj: | Respiratory Care. 64:145-152 |
| ISSN: | 1943-3654 0020-1324 |
| Popis: | BACKGROUND: There are limited longitudinal studies reporting predictive factors for decline in 6-min walk distance (6MWD) in patients with COPD. While previous studies have confirmed the association between air-flow limitation and decline in 6MWD, other factors have not been clarified. The objective of this study was to investigate whether exercise-induced oxygen desaturation (EID) could be a predictive factor for decline in 6MWD in patients with COPD. The interactive effect of air-flow limitation on the association between EID and decline in 6MWD was also investigated. METHODS: A longitudinal observational study was conducted with 71 out-patients with COPD who were followed for 1 year. 6MWD, EID, spirometry, and clinical characteristics were assessed. The effect of EID on changes in 6MWD was examined using linear regression analyses. Furthermore, the subjects were categorized into 4 groups according to their EID and air-flow limitation status, and changes in 6MWD were compared among the groups. RESULTS: 51 subjects completed the follow-up assessments, and 29 (56.9%) experienced EID. Multiple linear regression model revealed that EID was the only predictive factor for changes in 6MWD after adjusting for confounders (β = −38.9, P = .02). As results of multiple comparisons among the 4 groups based on EID and air-flow limitation status, changes in 6MWD in the EID and severe air-flow limitation group were the lowest. CONCLUSION: Our results revealed that EID was a predictive factor for decline in the functional capacity of subjects with COPD. The assessment of EID and air-flow limitation would thus be useful in estimating the prognosis of decline in the functional capacity of patients with COPD. |
| Databáze: | OpenAIRE |
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