Effects of thiopentone, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs
| Autor: | Roxanne K. Buck, Tesh M. Smalle, Marthinus Jacobus Hartman, Lynette Bester, Geoffrey T. Fosgate, Gareth E. Zeiler |
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| Rok vydání: | 2017 |
| Předmět: |
Larynx
medicine.medical_specialty 040301 veterinary sciences Movement Laryngoscopy Beagle Pregnanediones 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine 030202 anesthesiology medicine Animals Hypnotics and Sedatives Thiopental Propofol Cross-Over Studies General Veterinary medicine.diagnostic_test business.industry Alfaxalone Arytenoid cartilage 04 agricultural and veterinary sciences medicine.disease Crossover study Surgery medicine.anatomical_structure Laryngeal paralysis Anesthesia business Arytenoid Cartilage medicine.drug |
| Zdroj: | Veterinary Anaesthesia and Analgesia. 44:427-434 |
| ISSN: | 1467-2987 |
| DOI: | 10.1016/j.vaa.2016.05.013 |
| Popis: | Objective To compare the effects of thiopentone, propofol and alfaxalone on arytenoid cartilage motion and establish the dose rates to achieve a consistent oral laryngoscopy examination. Study design Randomised crossover study. Animals Six healthy adult Beagle dogs. Methods Each dog was randomly administered three induction agents with a 1-week washout period between treatments. Thiopentone (7.5 mg kg −1 ), propofol (3 mg kg −1 ) or alfaxalone (1.5 mg kg −1 ) was administered over 1 minute for induction of anaesthesia. If the dog was deemed inadequately anaesthetised, then supplemental boluses of 1.8, 0.75 and 0.4 mg kg −1 were administered, respectively. Continual examination of the larynx, using a laryngoscope, commenced once an adequate anaesthetic depth was reached until examination end point. The number of arytenoid motions and vital breaths were counted during three time periods and compared over time and among treatments. Data were analysed using Friedman and Mann–Whitney U tests, Spearman rho and a linear mixed model with post hoc pairwise comparison with Tukey correction. Results The median (range) induction and examination times were 2.8 (2.0–3.0), 2.7 (2.0–3.3) and 2.5 (1.7–3.3) minutes ( p = 0.727); and 14.1 (8.0–41.8), 5.4 (3.3–14.8) and 8.5 (3.8–31.6) minutes ( p = 0.016) for thiopentone, propofol and alfaxalone, respectively. The median dose rates required to achieve an adequate anaesthetic depth were 6.3 (6.0–6.6), 2.4 (2.4–2.4) and 1.2 (1.2–1.2) mg kg −1 minute −1 , respectively. There was no significant difference for the total number of arytenoid motions ( p = 0.662) or vital breaths ( p = 0.789) among induction agents. Conclusion and clinical relevance The number of arytenoid motions were similar among the induction agents. However, at the dose rates used in this study, propofol provided adequate conditions for evaluation of the larynx with a shorter examination time which may be advantageous during laryngoscopy in dogs. |
| Databáze: | OpenAIRE |
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