Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
Autor: | Julien E. Gautrot, Ton Peijs, Xi Zhang, William Megone |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
musculoskeletal diseases
electrospun fibers macromolecular substances complex mixtures composites Amphiphile Materials Chemistry Hydrogel composite Copolymer Carboxy methyl cellulose Polymers and polymer manufacture Materials of engineering and construction. Mechanics of materials hydrogels Chemistry Mechanical Engineering technology industry and agriculture musculoskeletal system TP1080-1185 Chemical engineering Mechanics of Materials Self-healing hydrogels Ceramics and Composites TA401-492 Surface modification poly(lactide acid) Photoinitiator biomaterials |
Zdroj: | Nanocomposites, Vol 6, Iss 3, Pp 85-98 (2020) |
ISSN: | 2055-0332 |
Popis: | Carboxy-methyl-cellulose (CMC) hydrogels, prepared in the presence of a crosslinker and photoinitiator, were reinforced with 3.7 wt% electrospun PLA fibers to create CMC hydrogel composites. To improve fiber-matrix adhesion, electrospun fiber mats based on hybrids of PLA and amphiphilic block copolymer (BCP) poly(D,L-lactide)-block-poly[2-(dimethylamino)ethyl methacrylate] (PLA-b-PDMAEMA) were produced. The presence of PDMAEMA at the fiber surface induced hydrophilic surface properties, which could be controlled by varying the PDMAEMA chain length. PDMAEMA was quaternized and co-electrospun with PLA fibers, which further enhanced the interaction between fibers and hydrogel matrix via ionic interactions. Physicochemical properties of the electrospun fiber mats and their CMC hydrogel based composites were assessed and revealed a nearly two orders of magnitude increase in modulus. Continuous electrospun fiber mats were chopped into discontinuous fibers to create short fiber reinforced CMC hydrogels. Rheological properties of these reinforced hydrogels incorporating 0.5 wt% discontinuous fibers were evaluated and showed potential as injectable composite systems for biomedical applications. |
Databáze: | OpenAIRE |
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