| Autor: |
George H. Neubauer, Dan H. Barouch, Michael R. Boyd, Peter Abbink, Rafael De La Barrera, Mark G. Lewis, Jessica Jimenez, Richard G. Jarman, Christine A. Bricault, David Jetton, Noe B. Mercado, Edward T. Moseley, Jean Pierre Schatzmann Peron, Stephen J. Thomas, Nelson L. Michael, Arshi Agarwal, Crystal Cabral, Mayuri Shetty, Amanda L. Brinkman, Galit Alter, Brad Finneyfrock, Marinela Kirilova, Ramya Nityanandam, Shanell Mojta, Erica N. Borducchi, Kayvon Modjarrad, Rafael A. Larocca, Zhenfeng Li, Katherine Molloy, Benjamin C. Lee, Paolo Marinho de Andrade Zanotto, Abishek Chandrashekar, Patricia B. Giglio, Kathryn E. Stephenson, Ovini Nanayakkara, Johnathan Misamore, David Ng’ang’a, Kenneth H. Eckels |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Science (New York, N.Y.). 353(6304) |
| ISSN: |
1095-9203 |
| Popis: |
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A plasmid DNA vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing ZIKV premembrane and envelope, also elicited neutralizing antibodies and completely protected monkeys against ZIKV challenge. These data support the rapid clinical development of ZIKV vaccines for humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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