Association between C-reactive protein and depression: modulated by gender and mediated by body weight
| Autor: | Jian Zhang, Rajai Jabrah, Fei Yan, Wei Wang, Yuexing Liu, Hasan Al-Sayegh |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Gerontology medicine.medical_specialty National Health and Nutrition Examination Survey Overweight Severity of Illness Index Body Mass Index Young Adult Sex Factors Predictive Value of Tests Internal medicine Odds Ratio Prevalence Humans Mass Screening Medicine Sex Distribution Biological Psychiatry Depression (differential diagnoses) Inflammation Depressive Disorder biology Depression business.industry Body Weight C-reactive protein Odds ratio Nutrition Surveys United States Patient Health Questionnaire Psychiatry and Mental health C-Reactive Protein Cross-Sectional Studies Quartile biology.protein Female medicine.symptom business Body mass index Biomarkers |
| Zdroj: | Psychiatry Research. 219:103-108 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2014.05.025 |
| Popis: | Literature on the relationship between depression and C-reactive protein (CRP), a biomarker of systematic inflammation, remains inconsistent. Insufficient adjustment for confounders and effect modifiers might be one explanation. We used the data of 6396 men and 6610 women aged 18 or older, who completed a depression screening and had blood collected as a part of the National Health and Nutrition Examination Survey, 2005-2010. Depression was measured using the 9-item depression scale of the Patient Health Questionnaire (PHQ-9). The odds ratios (ORs) of depression were 1.00 (reference), 1.89 (95% CI=0.77-4.67) and 3.41(1.25-9.25) respectively for men with low, intermediate and upper quartile of CRP. Adjustment for covariates, mainly body mass index, diminished the association among women, from 1.65(1.00-2.74) to 1.08(0.57-2.03) for intermediate, from 2.44 (1.43-4.16) to 1.05 (0.56-1.98) for upper quartile of CRP. Adjustment for the history of major medical illnesses changed ORs neither among men nor among women. The study concluded that CRP remained significantly associated with depression in a dose-response fashion among men but women after being adjusted for body weight. Abnormal body weight, both under and overweight, explained a substantial part of the relationship between CRP and depression among women. |
| Databáze: | OpenAIRE |
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