A novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone and a new isocoumarin isolated from the endophytic fungus Phoma sp. YN02-P-3
| Autor: | Shao-Fei Chen, Hai-Feng Wang, Yue-Hu Pei, Xia-Nan Sang, Xiao An, Gang Chen |
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| Rok vydání: | 2016 |
| Předmět: |
Stereochemistry
Pharmaceutical Science HL-60 Cells Naphthalenes Biology 010402 general chemistry 01 natural sciences Analytical Chemistry Inhibitory Concentration 50 chemistry.chemical_compound Isocoumarin phomasatin Ascomycota Drug Discovery Humans Spectral data Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure 010405 organic chemistry Organic Chemistry General Medicine Endophytic fungus biology.organism_classification 0104 chemical sciences Plant Leaves Isocoumarin Isocoumarins Complementary and alternative medicine chemistry Cell culture Phoma Molecular Medicine Two-dimensional nuclear magnetic resonance spectroscopy Heteronuclear single quantum coherence spectroscopy |
| Zdroj: | Journal of Asian Natural Products Research. 19:436-443 |
| ISSN: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2016.1217521 |
| Popis: | A novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone phomol (1) and a new isocoumarin phomasatin (2), together with two known compounds (3–4) were isolated from the solid culture of the endophytic fungus Phoma sp. YN02-P-3. Their structures including the absolute configurations were characterized on the basis of extensive 1D, 2D NMR (HSQC, HMBC, NOESY), MS, and CD spectral data. Compound 1 showed selective cytotoxic activity against HL-60 cell line with the IC50 value of 29.05 μM. |
| Databáze: | OpenAIRE |
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