Translational aspects of bone quality—vertebral fractures, cortical shell, microdamage and glycation: a tribute to Pierre D. Delmas
| Autor: | Mark R. Forwood, Deepak Vashishth |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Glycation End Products
Advanced Male medicine.medical_specialty Bone density Endocrinology Diabetes and Metabolism Osteoporosis Context (language use) Bone Density Glycation Bone quality medicine Humans Aged Aged 80 and over business.industry Anatomy Middle Aged Cortical shell medicine.disease Vertebra medicine.anatomical_structure Orthopedic surgery Spinal Fractures Female Stress Mechanical business |
| Zdroj: | Osteoporosis International. 20:247-253 |
| ISSN: | 1433-2965 0937-941X |
| DOI: | 10.1007/s00198-008-0791-z |
| Popis: | Among vertebral deformities, the prevalence of wedge fractures is about twice that of endplate (biconcave) deformities, both of which are greater than that of crush deformities. The anterior cortex is, therefore, a site of interest for understanding mechanisms of vertebral fracture. Despite its importance to vertebral mechanics, there are limited data describing the role of cortical shell, microdamage, and bone matrix parameters in vertebral fragility. This review of literature emphasizes the translational aspects of bone quality and demonstrates that a greater understanding of bone fractures will be gained through bone quality parameters related to both cortical and cancellous compartments as well as from microdamage and bone matrix parameters. In the context of vertebral fractures, measures of cortical shell and bone matrix parameters related to the organic matrix (advanced glycation products and alpha/beta CTX ratio) are independent of BMD measurements and can therefore provide an additional estimate of fracture risk in older patients. |
| Databáze: | OpenAIRE |
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