Acute hyperosmolar hyperglycaemic state in cystic fibrosis-related diabetes caused by glucocorticoid and itraconazole interaction
| Autor: | Craig Jefferies, Isaac T Bernhardt, Philip Moore, Sarah Currie |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Male medicine.medical_specialty Antifungal Agents Adolescent Cystic Fibrosis Itraconazole Cystic fibrosis-related diabetes Aspergillosis Cystic fibrosis Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Medicine Humans Drug Interactions Glucocorticoids Fluticasone CYP3A4 business.industry medicine.disease 030104 developmental biology 030228 respiratory system Diabetes Mellitus Type 2 Pediatrics Perinatology and Child Health Hyperglycemic Hyperosmolar Nonketotic Coma Pulmonary Aspergillosis business Glucocorticoid medicine.drug |
| Zdroj: | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 20(2) |
| ISSN: | 1873-5010 |
| Popis: | Hyperosmolar hyperglycaemic state (HHS) has not previously been reported in cystic fibrosis-related diabetes (CFRD). We report the case of a 15-year old boy with stable CFRD who developed acute HHS after treatment with glucocorticoids and itraconazole for presumed allergic broncho-pulmonary aspergillosis (ABPA). This case highlights the dangerous and preventable combination of high glucose intake, glucocorticoids and itraconazole inhibition of CYP3A4 (with resultant glucocorticoid accumulation) that can result in a state of life- threatening HHS in an adolescent with previously stable CFRD. |
| Databáze: | OpenAIRE |
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