Triclosan is a KCNQ3 potassium channel activator

Autor: VICTOR DE LA ROSA, Elisa Carrillo, Maria Luisa Guzman-Hernandez
Rok vydání: 2022
Předmět:
Zdroj: Pflügers Archiv - European Journal of Physiology. 474:721-732
ISSN: 1432-2013
0031-6768
Popis: KCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and 5. Activation of these channels silence the neurons, limiting action potential duration and preventing high-frequency action potential burst. Loss-of-function mutations of the KCNQ channels are associated with a wide spectrum of phenotypes characterized by hyperexcitability. Hence, pharmacological activation of these channels is an attractive strategy to treat epilepsy and other hyperexcitability conditions as are the evolution of stroke and traumatic brain injury. In this work we show that triclosan, a bactericide widely used in personal care products, activates the KCNQ3 channels but not the KCNQ2. Triclosan induces a voltage shift in the activation, increases the conductance, and slows the closing of the channel. The response is independent of PIP
Databáze: OpenAIRE
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