Long-term treatment with olanzapine in hospital conditions: Prevalence and predictors of the metabolic syndrome
| Autor: | Milutin Nenadovic, Slobodan M. Jankovic, Irena Popović, D. Ravanic, Dragan Milovanovic, Marko Folić, Milena Ilic, Albina Stanojević |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Olanzapine medicine.medical_specialty Cross-sectional study medicine.drug_class Population olanzapine Atypical antipsychotic lcsh:Medicine Drug Administration Schedule metabolic syndrome Benzodiazepines Internal medicine Diabetes mellitus Prevalence medicine Humans Family history Psychiatry education education.field_of_study business.industry lcsh:R General Medicine Middle Aged medicine.disease schizophrenia Cross-Sectional Studies Female Metabolic syndrome business Body mass index Antipsychotic Agents medicine.drug |
| Zdroj: | Srpski Arhiv za Celokupno Lekarstvo, Vol 143, Iss 11-12, Pp 712-718 (2015) |
| ISSN: | 2406-0895 0370-8179 |
| Popis: | Introduction. The risk of metabolic abnormalities is greatly increased in schizophrenic patients started on an atypical antipsychotic medication. Patients with psychiatric disorders exceed mortality ranges resulting from, among others, increased risk of cardiovascular events. Other factors contributing to the development of metabolic syndrome include prolonged duration of illness, increasing age, female sex and lifestyle factors. Objective. This cross-sectional study was taken up to assess the prevalence of the metabolic syndrome (MetS) in schizophrenic patients receiving olanzapine monotherapy for at least six months and to determine the most important risk factors associated with metabolic syndrome presence in these patients. Methods. A total of 93 long term hospitalized schizophrenic patients (71 men, 22 women), had a screening of the following: case-history data, psychiatric scales, anthropometric measures, blood (fasting glucose, lipid status, C-reactive protein - CRP) and urine samples (microalbuminuria). Results. Prevalence of MetS according to International Diabetes Federation criteria in our study was 34.4%. The multivariate analysis distinguished the following significant predictors of MetS presence (in order of appearance): data about diabetes mellitus in family history (p=0.002), body mass index >25 kg/m2 (p=0.002), hyperlipidemia in family history (p=0.008), and elevated CRP value (p=0.042). Conclusion. High rate of MetS in patients treated with olanzapine in this study exceeds MetS prevalence in general population. Among observed parameters, our study pointed to several “high risk” predictors associated with MetS presence. Regular monitoring of cardiometabolic risk factors is highly recommended. Positive heredity distress mentioned above may direct a psychiatrist to prescribe some other drug than olanzapine in the long term treatment of schizophrenia. |
| Databáze: | OpenAIRE |
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