Inhibition of carbohydrate-induced hypertriglyceridemia by metformin
| Autor: | Ivana Zavaroni, F. Bruschi, O. Alpi, Carlo Coscelli, Ugo Butturini, E. Dall'Aglio |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Hyperlipidemias Lipoproteins VLDL Biochemistry Intestinal absorption chemistry.chemical_compound Endocrinology Internal medicine medicine Dietary Carbohydrates Animals Insulin Secretion Triglycerides Biochemistry (medical) Hypertriglyceridemia Fructose Rats Inbred Strains General Medicine Carbohydrate medicine.disease Metformin Rats chemistry medicine.symptom Weight gain medicine.drug |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 16(2) |
| ISSN: | 0018-5043 |
| Popis: | The ability of metformin to prevent carbohydrate-induced hypertriglyceridemia was studied in fructose fed rats. The results indicated that plasma triglycerides were approximately 50% reduced in the drug treated rats and the reduction was associated with lowered very low density lipoprotein-triglyceride secretion rates and plasma insulin levels. Since the drug does not affect the fructose intestinal absorption, it did not prevent normal rate of weight gain. These results provide further evidence for the existence of a causal relationship between plasma TG concentration and plasma insulin concentration; metformin is able to modify both these variables likely affecting primarily the ambient insulin level. |
| Databáze: | OpenAIRE |
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