Acromegaly: clinical features at diagnosis
| Autor: | Clarice Freitas Vilar, Lucio Vilar, Ruy Lyra, Raissa Lyra, Luciana Ansaneli Naves |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Disease Gigantism 03 medical and health sciences 0302 clinical medicine Endocrinology Quality of life Pituitary adenoma Acromegaly medicine Humans Nose Dental malocclusion business.industry medicine.disease Disfigurement Dermatology medicine.anatomical_structure 030220 oncology & carcinogenesis Female business |
| Zdroj: | Pituitary. 20:22-32 |
| ISSN: | 1573-7403 1386-341X |
| DOI: | 10.1007/s11102-016-0772-8 |
| Popis: | Acromegaly is a rare and underdiagnosed disorder caused, in more than 95% of cases, by a growth hormone (GH)-secreting pituitary adenoma. The GH hypersecretion leads to overproduction of insulin-like growth factor 1 (IGF-1) which results in a multisystem disease characterized by somatic overgrowth, multiple comorbidities, physical disfigurement, and increased mortality. This article aims to review the clinical features of acromegaly at diagnosis. Acromegaly affects both males and females equally and the average age at diagnosis ranges from 40 to 50 years (up to 5% of cases |
| Databáze: | OpenAIRE |
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