Reduced CD8+ T-cell concentration in peripheral blood of patients with carotid artery stenosis: relation to arteritis temporalis
| Autor: | Elling H, A T Olsson, Elling P |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Giant Cell Arteritis Ischemia CD8-Positive T-Lymphocytes Leukocyte Count Rheumatology Internal medicine medicine Humans Pharmacology (medical) Carotid Stenosis cardiovascular diseases Arteritis Lymphocytes Aged Aged 80 and over business.industry Vascular disease Middle Aged medicine.disease Surgery Giant cell arteritis Stenosis Quartile Ischemic Attack Transient Cohort Cardiology Female business CD8 |
| Zdroj: | British journal of rheumatology. 35(7) |
| ISSN: | 0263-7103 |
| Popis: | The percentage and numbers of CD8+ T cells are markedly decreased in peripheral blood from patients with arteritis temporalis. Transient cerebral ischaemic attacks (TIA) or brain infarctions have been frequently reported as the first and only clinical manifestation, and signs of carotid artery stenosis have been reported in 15-20% of patients with arteritis temporalis. We used a determination of the CD8+ T-cell subset to evaluate patients with TIA. Concentrations of CD8+ T cells were measured in the peripheral blood of 24 patients with TIA. The cohort investigated was consecutive, but adjusted to have a 50% a priori probability of carotid artery stenosis. An ultrasound Doppler investigation of the carotid arteries was performed in all patients. Controls were 24 healthy subjects of comparable age and sex. Median percentage and concentrations of CD8+ T cells were significantly lower in patients with TIA and carotid artery stenosis compared with (1) patients with TIA and no carotid stenosis (CD8+ %: 13.5 vs 26; CD8+ x 10(9)/1: 0.24 vs 0.44, P < 0.001) and (2) healthy controls (CD8+ %: 13.5 vs 22.5; CD8+ x 10(9)/1: 0.24 vs 0.52, P < 0.001). The prevalence of a carotid artery stenosis in the combined first and second quartile of CD8+ % (CD8+ % |
| Databáze: | OpenAIRE |
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