Neurological development and iron supplementation in healthy late-preterm neonates: a randomized double-blind controlled trial
| Autor: | C Velli, C Dolci, Eugenio Mercuri, S Sivo, G. Mancini, Domenico M. Romeo, A Turriziani Colonna, Giovanni Vento, Costantino Romagnoli, Rita Paola Maria Luciano |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pediatrics Iron Gestational Age Placebo law.invention Psychomotor development 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Late preterm 030225 pediatrics medicine Humans 030212 general & internal medicine Neonatology Iron supplementation Psychomotor learning business.industry Iron deficiency Infant Newborn Infant Gestational age Iron Deficiencies medicine.disease Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA Dietary Supplements Pediatrics Perinatology and Child Health Original Article business Infant Premature |
| Zdroj: | European Journal of Pediatrics |
| ISSN: | 1432-1076 0340-6199 |
| Popis: | Late-preterm infants (LPT) are at increased risk for long-term neurodevelopmental sequelae and iron deficiency. The aim of the study is to assess the positive effect of iron supplementation on psychomotor development in healthy LPT. We designed a randomized placebo-controlled double-blind trial dividing the newborns into two groups. Every patient was assessed using the Griffiths Mental Development Scales (GMDS)-II edition at 12-month post-conceptional age. The study was performed at the Neonatology Unit of our Hospital, in Italy. Sixty-six healthy LPT infants born between 340⁄7 and 366⁄7 weeks of gestational age were enrolled in the study. One group received martial prophylaxis from the third week of life to 6 months of post-conceptional age (2 mg/kg/day of iron pidolate), the other received placebo. Fifty-two of the enrolled infants were assessed using the GMDS at 12-month of post-conceptional age. Statistical analysis of the mean scores of the Griffiths subscales was performed. There was a difference in the mean developmental quotient (DQ) (p Conclusions: We recommend that all LPT neonates receive iron supplementation during the first 6 months of life in order to improve their 1-year neurodevelopmental quotient. What is Known:• Late-preterm infants (LPT) are at increased risk for long-term neurodevelopmental sequelae and also for iron deficiency.• Iron deficiency is an independent risk factor for adverse neurological outcomes. What is New:• Healthy late-preterm who received iron supplementation during the first 6 months of life achieved better neurological outcomes at 12-month post-conceptional age than LPT who received placebo.• Our study strongly supports the need for the implementation of martial prophylaxis in LPT neonates. |
| Databáze: | OpenAIRE |
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