Technetium-99m pyrophosphate cardiac SPECT in endomyocardial biopsy negative cardiac amyloidosis
| Autor: | Rina Nguyen, Martin Krupa, Lester S. Johnson, Jonathan W. Revels |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty Amyloid lcsh:R895-920 Cardiac amyloidosis 030204 cardiovascular system & hematology Single-photon emission computed tomography Scintigraphy Transthyretin 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Cardiac magnetic resonance imaging medicine Radiology Nuclear Medicine and imaging biology medicine.diagnostic_test business.industry medicine.disease Tc-99m pyrophosphate Heart failure biology.protein cardiovascular system Radiology business Cardiac Technetium-99m |
| Zdroj: | Radiology Case Reports, Vol 13, Iss 5, Pp 925-928 (2018) Radiology Case Reports |
| ISSN: | 1930-0433 |
| Popis: | Cardiac amyloidosis is an under-appreciated cause of heart failure. Establishing a diagnosis is important because traditional heart failure treatment regimens can worsen left ventricular failure in this disease. Endomyocardial biopsy is the gold standard for diagnosis; however, scintigraphy with radiolabeled phosphate derivatives and cardiac magnetic resonance imaging have been shown to have high sensitivity and specificity in diagnosing cardiac amyloidosis. Furthermore, cardiac scintigraphy can reliably differentiate amyloid subtypes. We present a case of transthyretin-related cardiac amyloidosis with a negative endomyocardial biopsy but positive 99m-technetium pyrophosphate single photon emission computed tomography scan and cardiac magnetic resonance imaging. We discuss the utility of 99m-technetium pyrophosphate imaging in cardiac amyloidosis and the role of single photon emission computed tomography. Finally, we review the several forms of cardiac amyloidosis and how they pertain to cardiac scintigraphy. Keywords: Cardiac amyloidosis, Transthyretin, Tc-99m pyrophosphate |
| Databáze: | OpenAIRE |
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