Confocal microscopy reveals persisting stromal changes after myopic photorefractive keratectomy in zero haze corneas
| Autor: | Matthias Böhnke, Andreas Thaer, Isaak Schipper |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Refractive error Corneal endothelium Visual acuity genetic structures Corneal Stroma medicine.medical_treatment Confocal Excimer Photorefractive Keratectomy Cohort Studies Cellular and Molecular Neuroscience Cornea Myopia medicine Humans Wound Healing Microscopy Confocal business.industry Epithelium Corneal Anatomy Middle Aged Original articles - Clinical science medicine.disease eye diseases Sensory Systems Photorefractive keratectomy Contact lens Ophthalmology Cross-Sectional Studies medicine.anatomical_structure Lasers Excimer sense organs medicine.symptom business |
| Zdroj: | British Journal of Ophthalmology. 82:1393-1400 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.82.12.1393 |
| Popis: | AIMS—Micromorphological examination of the central cornea in myopic patients 8-43 months after excimer laser photorefractive keratectomy (PRK), using the slit scanning confocal microscope. METHODS—Patients were selected from a larger cohort of individuals on the basis of full corneal clarity (haze grading 0 to +1; mean 0.3) and their willingness to participate in the study. 15 eyes of 10 patients with myopic PRK (−4 to −11 D; mean 6.7) and an uneventful postoperative interval of 8-43 months (mean 26) were examined. Contact lenses had been worn by eight of the 10 patients for 4-11 years (mean 6.7) before surgery. Controls included the five untreated fellow eyes of PRK patients, 10 healthy, age matched volunteers without a history of ocular inflammation or contact lens wear, and 20 patients who had worn rigid gas permeable (n=10) or soft contact lenses (n=10) for 2-11 years. Subjects were examined with a real time flying slit, scanning confocal microscope using ×25 and ×50 objectives. RESULTS—In PRK treated patients and contact lens wearers, basal layer epithelial cells sporadically displayed enhanced reflectivity. The subepithelial nerve plexus was observed in all individuals, but was usually less well contrasted in the PRK group, owing to the presence of a very discrete layer of subepithelial scar tissue, which patchily enhanced background reflectivity. Within all layers of the stroma, two distinct types of abnormal reflective bodies were observed in all PRK treated eyes, but in none of the controls. One had the appearance of long (>= 50 µm), slender (2-8 µm in diameter) dimly reflective rods, which sometimes contained bright, punctate, crystal-like inclusions, arranged linearly and at irregular intervals. The other was shorter ( |
| Databáze: | OpenAIRE |
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