Сardiac injury in rats with experimental posttraumatic stress disorder and mechanisms of its limitation in experimental posttraumatic stress disorder-resistant rats
| Autor: | Alexey Sarapultsev, Eugenia B. Manukhina, Vladimir A Mkhitarov, H. Fred Downey, Vadim Tseilikman, Yulia A Dmitrieva, Anna V. Goryacheva, Maria Komelkova, Olga P. Kuzhel, Marina V. Kondashevskaya, Svetlana S. Lazuko, Maxim S. Lapshin, Viktor K Strizhikov, Olga B. Tseilikman |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Heart Injury Physiology Inflammation Anxiety medicine.disease_cause Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine mental disorders medicine Animals business.industry Myocardium Rats 030227 psychiatry Oxidative Stress Posttraumatic stress Endocrinology medicine.symptom business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of Applied Physiology. 130:759-771 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00694.2019 |
| Popis: | NEWS and NOTEWORTHY For the first time, rats exposed to stress were segregated into experimental PTSD (ePTSD)-susceptible and ePTSD-resistant rats. Cardiac injury, ECG changes, and impaired exercise tolerance were more pronounced in ePTSD-susceptible rats. Resistance to ePTSD was associated with decreased inflammation and oxidative stress and with increased protective heat shock protein 70. Results may help identify individuals at high risk of PTSD and also provide a foundation for developing preventive and therapeutic means to restrict PTSD-associated cardiac morbidity. |
| Databáze: | OpenAIRE |
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