Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues

Autor:	Peter Petersen, Tarek S. Mansour, Douglas M. Ho, Emily B. Norton, Guy Singh, Beth A. Rasmussen, Ayako Yamashita, Youjin Yang
Rok vydání:	2003
Předmět:	Stereochemistry education Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Peptidoglycan Biochemistry Phospho-N-acetylmuramoyl-pentapeptide-transferase Cell membrane Structure-Activity Relationship chemistry.chemical_compound Biosynthesis Drug Discovery medicine Urea Molecular Biology Antibacterial agent chemistry.chemical_classification biology Lipid II Nucleotides Organic Chemistry humanities medicine.anatomical_structure Enzyme chemistry Enzyme inhibitor biology.protein Molecular Medicine Peptides
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:3345-3350
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00671-1
Popis:	A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ad5391cf0545fc933c09268407bc72 https://doi.org/10.1016/s0960-894x(03)00671-1 Zobrazit plný text záznamu Full Text from ScienceDirect